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Animal Study of Photodynamic Therapy with Verteporfin in Corneal Neovascularization
Journal of the Korean Ophthalmological Society ; : 707-715, 2005.
Artigo em Coreano | WPRIM | ID: wpr-185636
ABSTRACT

PURPOSE:

To determine the efficacy of photodynamic therapy (PDT) with verteporfin (Visudyne(R), Norvatis Ophthalmics AG, Hettingen, Switzerland), a benzoporphyrin derivative, in the treatment of corneal neo-vascularization (CN) in a rabbit eye model.

METHODS:

CN was induced by placing instrastromal sutures in the cornea. Two weeks after suturing, verteporfin was administrated intravenously and 1 hour later, the right eye (treated group) was exposed to a laser with a 689 nm wavelength, and the left eye was used as the control. The changes in CN were analyzed using biomicroscopy and optical microscopy in twelve rabbits.

RESULTS:

The mean percentages of the neovascular area in the control and treated groups were 96.4 +/- 1.9% and 90.3 +/- 3.5% (P=0.009) at three days after the PDT, 88.6 +/- 4.6% and 71.6 +/- 6.2% (P<0.001) at one week, and 76.8 +/- 4.4% and 43.6 +/- 15.1% (P<0.001) at two weeks, respectively. Optical microscopy showed significant differences between the control and treated group in terms of the area and number of CN (P<0.05).

CONCLUSIONS:

PDT with verteporfin is a safe and effective procedure for regressing CN. However, a further study will be necessary.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fotoquimioterapia / Suturas / Neovascularização da Córnea / Córnea / Microscopia Limite: Animais Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fotoquimioterapia / Suturas / Neovascularização da Córnea / Córnea / Microscopia Limite: Animais Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Ano de publicação: 2005 Tipo de documento: Artigo