Cancer Epigenetics / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 1-12, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-185702
ABSTRACT
Knowledge regarding molecular events of cancer development has been rapidly accumulated during the last decade. The discovery of tumor suppressor gene-silencing by aberrant promoter CpG island hypermethylation and histone-directed chromatin remodeling has led epigenetics to its recognition as an important alternative mechanism for carcinogenesis. Epigenetics does not involve changes in nucleotide sequences, but it affects on genetic composition in many ways. Cancer cells integratively co-opt genetic and epigenetic mechanisms to acquire different aspects of carcinogenetic phenotypes. Since epigenetic changes can be reversed with relative ease, the research of cancer epigenetics provides great potential for new therapeutic regimens.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resumo em Inglês
/
Transformação Celular Neoplásica
/
Genes Supressores de Tumor
/
Regiões Promotoras Genéticas
/
Impressão Genômica
/
Ilhas de CpG
/
Metilação de DNA
/
Inativação Gênica
/
Neoplasias
Limite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2004
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS