Exophthalmos Inhibitory Effect of Anti-EPS Serum

ABSTRACT

Gold fishes were used to determine exophthalmos-inhibitory effect of anti-EPS serum. Anti-EPS Serum was obtained by repeated injection of serum from a patient of malignant exophthalmos to a guinea pig. The exophthalmos-inhibitory effect on fish was determined by measuring the intercorneal distance of fishes by the use of a micrometer before and after the injection of sera, and the percentage in that distance were calculated. The responsiveness of fishes was partly controlled by the injections of normal guinea pig serum and the serum from a patient of endocrine exophthalmos. The injections of the serum from the patient provoked exophthalmos. The injections of the serum from the patient, followed by the injections of normal serum of guinea pig provoked no exophthalmos. The injections of the patient's serum followed by injections of antiserum of guinea pig resulted in marked enophthalmos. These results suggest that the normal guinea pig serum and the antiserum from the guinea pig contains exophthalmos-inhibitory factor, and that this effect was greater in the serum treated by patient's serum.