IL-5 Promoter Polymorphism Enhances IgE Responses to Staphylococcal Superantigens in Adult Asthmatics
Allergy, Asthma & Immunology Research
; : 106-109, 2013.
Article
em En
| WPRIM
| ID: wpr-186062
Biblioteca responsável:
WPRO
ABSTRACT
Interleukin 5 (IL-5) is a key cytokine involved in the induction of T-helper type 2 (Th2) responses in the asthmatic airway. We investigated IL-5 genetic polymorphisms associated with asthma phenotypes, including IgE responses to staphylococcal enterotoxins A and B (SEA and SEB, respectively), in asthmatics. Adult asthmatics (n=310) and normal controls (n=160) were enrolled in the present study. Serum total and specific IgE to SEA and SEB were measured. Two IL-5 polymorphisms, -746A>G and +4499T>G, were genotyped using the primer-extension method. There were no significant differences in genotype or haplotype frequencies of these polymorphisms between the two groups. Asthmatics carrying the AG/GG genotype at -746A>G had a significantly higher prevalence of serum specific IgE to SEA (P=0.008), higher total IgE levels (P=0.014), and lower PC20 methacholine levels (P=0.002) compared to those with the AA genotype. These findings suggest that the IL-5 promoter polymorphism at -746A>G enhances serum total and specific IgE responses to SEA, which may augment airway hyperresponsiveness in adult asthmatics.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fenótipo
/
Polimorfismo Genético
/
Asma
/
Haplótipos
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Imunoglobulina E
/
Prevalência
/
Cloreto de Metacolina
/
Interleucina-5
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Superantígenos
/
Remoção
Tipo de estudo:
Prevalence_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Allergy, Asthma & Immunology Research
Ano de publicação:
2013
Tipo de documento:
Article