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Serum γ-Glutamyl Transferase Is Inversely Associated with Bone Mineral Density Independently of Alcohol Consumption
Endocrinology and Metabolism ; : 64-71, 2016.
Artigo em Inglês | WPRIM | ID: wpr-186229
ABSTRACT

BACKGROUND:

γ-Glutamyl transferase (GGT) is a well-known marker of chronic alcohol consumption or hepatobiliary diseases. A number of studies have demonstrated that serum levels of GGT are independently associated with cardiovascular and metabolic disorders. The purpose of this study was to test if serum GGT levels are associated with bone mineral density (BMD) in Korean adults.

METHODS:

A total of 462 subjects (289 men and 173 women), who visited Severance Hospital for medical checkup, were included in this study. BMD was measured using dual energy X-ray absorptiometry. Cross-sectional association between serum GGT and BMD was evaluated.

RESULTS:

As serum GGT levels increased from the lowest tertile (tertile 1) to the highest tertile (tertile 3), BMD decreased after adjusting for confounders such as age, body mass index, amount of alcohol consumed, smoking, regular exercise, postmenopausal state (in women), hypertension, diabetes mellitus, and hypercholesterolemia. A multiple linear regression analysis showed a negative association between log-transformed serum GGT levels and BMD. In a multiple logistic regression analysis, tertile 3 of serum GGT level was associated with an increased risk for low bone mass compared to tertile 1 (odds ratio, 2.271; 95% confidence interval, 1.340 to 3.850; P=0.002).

CONCLUSION:

Serum GGT level was inversely associated with BMD in Korean adults. Further study is necessary to fully elucidate the mechanism of the inverse relationship.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fumaça / Transferases / Consumo de Bebidas Alcoólicas / Fumar / Absorciometria de Fóton / Índice de Massa Corporal / Densidade Óssea / Modelos Lineares / Modelos Logísticos / Diabetes Mellitus Tipo de estudo: Fatores de risco Limite: Adulto / Humanos / Masculino Idioma: Inglês Revista: Endocrinology and Metabolism Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fumaça / Transferases / Consumo de Bebidas Alcoólicas / Fumar / Absorciometria de Fóton / Índice de Massa Corporal / Densidade Óssea / Modelos Lineares / Modelos Logísticos / Diabetes Mellitus Tipo de estudo: Fatores de risco Limite: Adulto / Humanos / Masculino Idioma: Inglês Revista: Endocrinology and Metabolism Ano de publicação: 2016 Tipo de documento: Artigo