Glomerular C4d Deposition Indicates in situ Classic Complement Pathway Activation, but is not a Marker for Lupus Nephritis Activity
Yonsei Medical Journal
;
: 75-80, 2003.
Artigo
em Inglês
| WPRIM
| ID: wpr-186278
ABSTRACT
This study was designed to evaluate whether glomerular C4d deposition may be a useful marker of lupus nephritis activity. Twenty-one patients diagnosed as having lupus nephritis (WHO class III 4 cases; IV 12 cases; V 5 cases) were included. Mean patient age was 29.3 +/- 13.5 years (range 7-55 years). The presence and intensity of glomerular C4d deposition were compared with the corresponding histologic activity index for each case. Immunofluorescence for C4d showed diffusely granular staining along glomerular capillary loops, in all cases examined (1+, in 8 cases; 2+, in 7 cases; 3+, in 6cases). In eight cases, C4d deposition was found in the absence of capillary or mesangial C4 deposits. Moreover, the intensity of C4d deposits correlated with those of capillary IgG, IgA, C4, C1q, and fibrinogen deposits. However, C4d staining intensity did not correlate with the lupus nephritis activity index. Although glomerular capillary C4d deposition is a sensitive marker of classic complement pathway activation, it is not a sensitive marker for active lupus nephritis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fragmentos de Peptídeos
/
Índice de Gravidade de Doença
/
Nefrite Lúpica
/
Complemento C4
/
Biomarcadores
/
Via Clássica do Complemento
/
Glomérulos Renais
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2003
Tipo de documento:
Artigo
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