Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control
Experimental & Molecular Medicine
;
: e181-2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-186438
ABSTRACT
Middle East respiratory syndrome coronavirus (MERS-CoV) causes high fever, cough, acute respiratory tract infection and multiorgan dysfunction that may eventually lead to the death of the infected individuals. MERS-CoV is thought to be transmitted to humans through dromedary camels. The occurrence of the virus was first reported in the Middle East and it subsequently spread to several parts of the world. Since 2012, about 1368 infections, including ~487 deaths, have been reported worldwide. Notably, the recent human-to-human \'superspreading' of MERS-CoV in hospitals in South Korea has raised a major global health concern. The fatality rate in MERS-CoV infection is four times higher compared with that of the closely related severe acute respiratory syndrome coronavirus infection. Currently, no drug has been clinically approved to control MERS-CoV infection. In this study, we highlight the potential drug targets that can be used to develop anti-MERS-CoV therapeutics.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Linhagem Celular
/
Surtos de Doenças
/
Infecções por Coronavirus
/
Dipeptidil Peptidase 4
/
Interações Hospedeiro-Patógeno
/
Descoberta de Drogas
/
Terapia de Alvo Molecular
/
Glicoproteína da Espícula de Coronavírus
/
Coronavírus da Síndrome Respiratória do Oriente Médio
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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