Interstitial Photodynamic Therapy (PDT) Set-up for Treating Solid Tumor Using Laser Diode / 의학물리
Korean Journal of Medical Physics
;
: 104-109, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-187030
ABSTRACT
Photodynamic therapy (PDT) is one of the expectable current cure operation methods. Tumor tissue is treated by abundant oxygen in a body and generated singlet or free radical from exterior laser diode and photosensitizer. Current problem of PDT is the low penetration power of the light beam in a deep seated large tumor and solid tumor thus results in low treatment outcome. In the study, we tried to develop interstitial photodynamics therapy treatment to solve this problem. As the accurate determination of light dosimetry in biological tissue is one of the most important factors affecting the effectiveness of PDT, parameters used in this study are the optical property of biological tissue. Since biological tissues have large scattering coefficient to visible light the penetration depth of a biological tissue in visible light region is only 15~20 mm. We showed that it is possible to measure fluence rate and penetration depth within the biological tissues by Monte Carlo simulation very well. Based on the MC simulation study, the effectiveness of interstitial photodynamic therapy on tumor control in solid tumor was proved through in vivo animal experiment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Fotoquimioterapia
/
Resultado do Tratamento
/
Experimentação Animal
/
Luz
Idioma:
Coreano
Revista:
Korean Journal of Medical Physics
Ano de publicação:
2005
Tipo de documento:
Artigo
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