Nontuberculous mycobacterial infection in rheumatoid arthritis patients: a single-center experience in South Korea
The Korean Journal of Internal Medicine
;
: 1090-1097, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-187137
ABSTRACT
BACKGROUND/AIMS:
Nontuberculous mycobacteria (NTM) infection has been increasing worldwide in both general population and immunocompromised patients, which has also been reported in rheumatoid arthritis (RA) patients. This study aimed to identify the incidence and clinical characteristics of NTM infection in RA patients living in tuberculosis (TB) infection endemic area.METHODS:
We performed a retrospective analysis of NTM infection cases in our RA registry at a tertiary referral center from January 1995 to December 2013. The clinical features of them were compared to those of 52 TB infection patients from same registry.RESULTS:
Among 1,397 patients with RA, NTM infection was newly developed in 26 patients and the incidence of NTM infection was 164.8 per 100,000 patient-years. The Mycobacterium avium complex was the most frequent isolate (76.9%). None of the NTM infections had extrapulmonary involvement, which was rather common in TB infection (26.9%). Patients with NTM infection were older, received higher cumulative steroid doses, and had higher rates of past TB infection history and concomitant interstitial lung disease (ILD) than cases with TB infection.CONCLUSIONS:
In South Korea, NTM infection is not rare in RA patients, and infection rates are growing. Physicians should be cautious about NTM infection in patients with a history of TB infection or concomitant ILD, even living in TB endemic area.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artrite Reumatoide
/
Tuberculose
/
Complexo Mycobacterium avium
/
Incidência
/
Estudos Retrospectivos
/
Hospedeiro Imunocomprometido
/
Doenças Pulmonares Intersticiais
/
Centros de Atenção Terciária
/
Coreia (Geográfico)
/
Micobactérias não Tuberculosas
Tipo de estudo:
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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