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Effects of Prenatal Stress and Restraint Stress on Amygdala Complex of the Rat: II. Effects on the Astrocytic Cell Processes / 체질인류학회지
Korean Journal of Physical Anthropology ; : 235-243, 2008.
Artigo em Coreano | WPRIM | ID: wpr-18720
ABSTRACT
The hypothesis that adverse experience alters the balance of neurotransmitters in the amygdala rendering it hyperresponsive to stress was examined in the present study. Since astrocytes regulate the brain's neurochemical milieu by uptaking neurotransmitters, we have examined these cells in the amygdala of prenatally stressed rats, a model of pathological anxiety. Here we examined morphometric changes on the cell bodies of astrocytes in the amygdala induced by prenatal stress and restraint stress. For this purpose, rats were classified into 4 groups; control group (CON), only restraint stressed (starting on P90 for 3 days) group (CONR), prenatally stressed group (PNS), and prenatally and restraint (on P90 for 3 days) stressed group (PNSR). Astrocytes stained with GFAP immunohistochemistry were counter stained with methylene blue/azure II and were examined using the Neurolucida. The present study showed that prenatal and restraint stress caused the significant increase in the total number and length of the amygdaloid astrocytic processes. In conclusion, astrocytes show structural indices of activation with stress.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ansiedade / Compostos Organotiofosforados / Imuno-Histoquímica / Astrócitos / Neurotransmissores / Tonsila do Cerebelo Limite: Animais Idioma: Coreano Revista: Korean Journal of Physical Anthropology Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ansiedade / Compostos Organotiofosforados / Imuno-Histoquímica / Astrócitos / Neurotransmissores / Tonsila do Cerebelo Limite: Animais Idioma: Coreano Revista: Korean Journal of Physical Anthropology Ano de publicação: 2008 Tipo de documento: Artigo