A Case of Atypical McCune-Albright Syndrome Associated with Hyperthyroidism and Hypersecretion of Growth Hormone / 대한내분비학회지
Journal of Korean Society of Endocrinology
;
: 426-432, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-187343
ABSTRACT
McCune-Albright syndrome is characterized by polyostotic fibrous dysplasia, Caf -au-lait pigmentation and precocious puberty or other endocrinopathy. It can be caused by substitution of His, Cys or Gly for Arg 201st amino acid of the Gs protein subunit. The case of a 32-year-old woman, with atypical McCune-Albright syndrome, is reported. She had no skin lesion or precocity puberty. The polyostotic fibrous dysplasia was examined by a simple radiological image and whole body scan. She developed hyperthyroidism, with a multinodular toxic goiter. No thyroid related autoantibodies were detected. The cause of hyperthyroidism was thought to be a non- autoimmune thyroid hyperfunction. The level of growth hormone was not suppressed by oral glucose load. After a bromocriptine suppression test, the level of growth hormone decreased. There was no mass in the pituitary gland on a sellar MRI. A case of atypical McCune-Albright syndrome, including hyperthyroidism and hypersecretion of growth hormone, is reported.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hipófise
/
Puberdade Precoce
/
Pele
/
Autoanticorpos
/
Glândula Tireoide
/
Pigmentação
/
Hormônio do Crescimento
/
Imageamento por Ressonância Magnética
/
Bromocriptina
/
Puberdade
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Society of Endocrinology
Ano de publicação:
2003
Tipo de documento:
Artigo
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