Der p 1, Der p 2 and Der p 10 IgE Reactivities in Allergic Rhinitis Patients in Korea
Journal of Rhinology
;
: 91-96, 2016.
Artigo
em Coreano
| WPRIM
| ID: wpr-187447
ABSTRACT
BACKGROUND AND OBJECTIVES:
To evaluate IgE reactivity profiles to Der p 1, Der p 2, and Der p 10 in house dust mite (HDM) allergic rhinitis (AR) patients in Korea. Symptomatic and serologic changes after sublingual immunotherapy (SLIT) were analyzed according to IgE profiles. MATERIALS ANDMETHODS:
Sixty AR patients diagnosed with an HDM allergy were tested for the presence of IgE antibodies against purified HDM allergen molecules (i.e., nDer p 1, rDer p 2, and rDer p 10) and native Dermatophagoides pteronyssinus (Dp) using ImmunoCAP 250®. Symptom scores and laboratory findings were analyzed after SLIT.RESULTS:
Prevalence rates of IgE for Dp, Der p 1, Der p 2, and Der p 10 were 100%, 98.3%, 93.3%, and 8.3%, respectively. After one year of immunotherapy with SLITone○R (standardized to major allergens, but not Der p 10), symptom scores and laboratory findings improved in patients with and without Der p 10 IgE antibodies.CONCLUSION:
In Korean AR patients, specific IgE antibodies to Der p 1 or Der p 2 are present in most Dp-allergic patients, while reactivity to Der p 10 is very low. Allergic symptoms improved in patients with Der p 10 IgE antibodies after SLIT.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Imunoglobulina E
/
Alérgenos
/
Prevalência
/
Pyroglyphidae
/
Dermatophagoides pteronyssinus
/
Antígenos de Dermatophagoides
/
Imunoterapia Sublingual
/
Rinite Alérgica
/
Hipersensibilidade
/
Imunoterapia
Tipo de estudo:
Estudo de prevalência
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Journal of Rhinology
Ano de publicação:
2016
Tipo de documento:
Artigo
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