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Mechanism of Anti-α-Synuclein Immunotherapy
Journal of Movement Disorders ; : 14-19, 2016.
Artigo em Inglês | WPRIM | ID: wpr-187648
ABSTRACT
Immunization therapy targeting α-synuclein has emerged as a promising approach for Parkinson's disease and perhaps for other synucleinopathies. Several antibodies have shown therapeutic effects in mouse models of synucleinopathies and have alleviated the pathological and behavioral phenotypes of these mice. The mechanisms through which the immunization therapy works were initially puzzling, especially given that α-synuclein is a typical cytosolic protein. Recent studies, however, suggested that extracellular α-synuclein is an important pathogenic entity, and hence, a target for immunotherapy. Here, we review the literature describing immunization therapy for synucleinopathies in mouse models and provide current thoughts on the potential mechanisms underlying the therapeutic effects of α-synuclein immunotherapy.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doença de Parkinson / Fenótipo / Imunização / Citosol / Usos Terapêuticos / Imunoterapia / Anticorpos Limite: Animais Idioma: Inglês Revista: Journal of Movement Disorders Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doença de Parkinson / Fenótipo / Imunização / Citosol / Usos Terapêuticos / Imunoterapia / Anticorpos Limite: Animais Idioma: Inglês Revista: Journal of Movement Disorders Ano de publicação: 2016 Tipo de documento: Artigo