The Clinical Usefulness of Cystatin C in Evaluating Renal Function in Children with Various Renal Diseases
Journal of the Korean Society of Pediatric Nephrology
;
: 161-167, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-187884
ABSTRACT
PURPOSE:
GFR(glomerular filtration rate) is a fundamental parameter in detecting renal impairment and predicts the progression of renal disease. Because serum creatinine has several disadvantages, serum cystatin C has been recently proposed as a new endogenous marker for GFR. We compared serum cystatin C with creatinine and creatinine clearance to investigate the clinical usefulness of cystatin C.METHODS:
We retrospectively analyzed 46 patients(60 case numbers) who had various renal diseases and classified them into 3 groups according to creatinine clearance(Group 1 CrCl 60 mL/min/1.73 m2). We measured serum creatinine, cystatin C and creatinine clearance and also analyzed the correlations among them.RESULTS:
Serum cystatin C and creatinine showed a similar correlation to creatinine clearance (r=0.685, r=0.640, respectively) and showed similar diagnostic accuracy in detecting decreased GFR(AUC, cystatin C 0.829 vs. creatinine 0.826, P=0.848). Serum cystatin C showed a greater sensitivity for detecting a decreased GFR than creatinine in Group 2 and 3(Group 1 100% vs. 100%, Group 2 70% vs. 35%, Group 3 46% vs. 15%).CONCLUSIONS:
Serum cystatin C could be a useful endogenous marker for GFR and would be superior to serum creatinine in early detection of renal impairment in pediatric patients with renal diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estudos Retrospectivos
/
Creatinina
/
Cistatina C
/
Filtração
/
Taxa de Filtração Glomerular
Tipo de estudo:
Estudo observacional
/
Estudo de rastreamento
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Society of Pediatric Nephrology
Ano de publicação:
2007
Tipo de documento:
Artigo
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