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Eight-Week Prospective Open-Label Trial of the Treatment Efficacy of Aripiprazole in Children with Tourette Syndrome / 대한정신약물학회지
Korean Journal of Psychopharmacology ; : 384-389, 2006.
Artigo em Coreano | WPRIM | ID: wpr-187941
ABSTRACT

OBJECTIVE:

It is postulated that since aripiprazole is a dopamine partial agonist and serotonin 2A receptor antagonist, aripiprazole may be effective in Tourette syndrome with few of extrapyramidal side effects. This open label study assessed the effectiveness of aripiprazole in children with Tourette syndrome (TS).

METHOD:

Nineteen children, aged 6 to 13 years, diagnosed with TS were participated in a 8-week open label trial. Efficacy assessments included Korean form of Yale Global Tic Severity Scale (K-YGTSS) and Clinical Global Impression scores. Safety and tolerability evaluations included extrapyramidal symptoms and effects on weight, prolactin, and corrected QT (QTc) interval.

RESULTS:

A significant decrease in TS symptoms, on all scales measured, appeared in 2 weeks. Adverse effects were mild and not significant. The most frequent side effects were somnolence, light headedness and headache.

CONCLUSIONS:

The results of current open label trial suggests the effectiveness of aripiprazole and few of side effects in the treatment of children with TS. Double-blind, placebo-, and active comparator-controlled studies are indicated to rigorously test of the efficacy of aripiprazole in TS.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prolactina / Pesos e Medidas / Dopamina / Síndrome de Tourette / Estudos Prospectivos / Resultado do Tratamento / Tiques / Receptor 5-HT2A de Serotonina / Tontura / Aripiprazol Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional Limite: Criança / Humanos Idioma: Coreano Revista: Korean Journal of Psychopharmacology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prolactina / Pesos e Medidas / Dopamina / Síndrome de Tourette / Estudos Prospectivos / Resultado do Tratamento / Tiques / Receptor 5-HT2A de Serotonina / Tontura / Aripiprazol Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional Limite: Criança / Humanos Idioma: Coreano Revista: Korean Journal of Psychopharmacology Ano de publicação: 2006 Tipo de documento: Artigo