Detection of Treponema pallidum by polymerase chain reaction in the cerebrospinal fluid of syphilis patients
Yonsei Medical Journal
;
: 190-197, 1994.
Artigo
em Inglês
| WPRIM
| ID: wpr-188864
ABSTRACT
To find out if polymerase chain reaction could be used as a diagnostic tool for detecting neurosyphilis, we have applied the PCR for the detection of Treponema pallidum DNA in the cerebrospinal fluid (CSF) of syphilis patients. The results of the PCR of the CSF in 26 patients with at various stages of illness were compared with the results of other conventional tests used in the WHO criteria. T. pallidum was detected in the CSF of patients at all stages of syphilis, which indicates that they invade the central nervous system from the early stages of infection. However, the presence of T. pallidum in the CSF was not correlated with the results of other tests used in the WHO criteria, and its significance in the diagnosis of neurosyphilis should further be evaluated.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Treponema pallidum
/
DNA Bacteriano
/
Líquido Cefalorraquidiano
/
Reação em Cadeia da Polimerase
/
Sensibilidade e Especificidade
/
Neurossífilis
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
1994
Tipo de documento:
Artigo
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