Gamma/delta T lymphocytes in the BCG granulomatous lesions
Yonsei Medical Journal
;
: 319-324, 1996.
Artigo
em Inglês
| WPRIM
| ID: wpr-189354
ABSTRACT
Recent studies in man and animal models have demonstrated that TCR-gamma delta-bearing T cells (gamma delta T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. Although the function of gamma delta T cells remains unclear, some data suggest a potential role for these cells in the granulomatous immune response. To address the presence of gamma delta T cells within the BCG granulomas, we have characterized the TCR phenotype of T-lymphocytes present in the BCG granulomatous lesion immunohistochemically using a monoclonal antibody to TCR delta 1 and others. Fairly large numbers of gamma delta T cells were located at the periphery of the BCG granulomas without necrosis and most of them also expressed CD8. However, gamma delta T cells were rarely present in the granulomas with central caseous necrosis, calcification and fibrotic changes. With these results, it might be speculated that the CD8+ gamma delta T lymphocytes participate in the BCG granuloma formation mainly in the early stage.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tuberculose
/
Linfócitos T
/
Receptores de Antígenos de Linfócitos T gama-delta
/
Granuloma
/
Linfonodos
/
Mycobacterium bovis
Limite:
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
1996
Tipo de documento:
Artigo
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