The Effect of Urokinase on the Hyphema in Rabbits

ABSTRACT

In 20 eyes of 10 rabbits, total hyphema were produced by injecting human fresh blood into the anterior chamber after aspirating the aquous humor. six hours later, 10 left eyes of them were treated with injection of urokinase into the anterior chamber. A control group of 5 right eyes were treated with normal saline and the other 5 right eyes were left untreated. The eyes treated with urokinase showed the most rapid rate of absorption of blood clot and clearance of corneal opacity among 3 groups. The comparison between the group treated with normal saline and the untreated group about the absorption rate of blood clot and clearance of corneal opacity were made. The former is slightly rapid than the later, but there was no significant differance between them. The observation of ciliary injection and changes of intraocular pressure had not shown a significant differance among 3 groups.