Roles of Matrix Metalloproteinases and Their Targets in Epileptogenesis and Seizures
Clinical Psychopharmacology and Neuroscience
;
: 45-52, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-189613
ABSTRACT
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which together regulate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathological conditions. Recent studies have suggested that prolonged seizures are associated with high MMP levels in serum and neural tissues, and certain extracellular macromolecule targets may influence the pathogenesis of epilepsy and seizure. In this review, we discuss the roles of MMP activation in animal models of epilepsy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Convulsões
/
Adesão Celular
/
Proteínas da Matriz Extracelular
/
Receptores de Neurotransmissores
/
Potenciação de Longa Duração
/
Metaloproteinases da Matriz
/
Modelos Animais
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Metaloproteases
/
Epilepsia
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2013
Tipo de documento:
Artigo
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