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Protective effect of ethyl acetate extract of Ishige okamurae against carbon tetrachloride-induced acute liver injury in rats / 대한수의학회지
Korean Journal of Veterinary Research ; : 259-265, 2011.
Artigo em Inglês | WPRIM | ID: wpr-189764
ABSTRACT
Several compounds and extracts isolated from a brown alga, Ishige (I.) okamurae, exhibit anti-oxidant and anti-inflammatory effects. The present study investigated whether the ethyl acetate (EtOAc) fraction of I. okamurae (EFIO) could ameliorate carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Sprague-Dawley rats were intraperitoneally (i.p.) administered with EFIO at 10 or 50 mg/kg per day for 2 consecutive days before CCl4 injection (3.3 mL/kg, i.p.). Twenty four hours later, the rats were anesthesized with diethyl ether and dissected. Pretreatment with EFIO significantly reduced the increased serum levels of alanine aminotransferase and aspartate aminotransferase in CCl4-treated rats. Pretreatment with EFIO also significantly inhibited the reduced activities of superoxide dismutase and catalase in the CCl4-injured liver. Histopathological evaluations showed that hemorrhage, hepatocyte necrosis, inflammatory cell infiltration, and fatty degeneration induced by CCl4 treatment were ameliorated by the administration of EFIO. Additionally, liver immunohistochemical analyses revealed the marked reduction in ED1-positive monocyte-like macrophages in EFIO-pretreated rats given CCl4. These results suggest that EFIO ameliorates CCl4-induced liver injury, possibly through the inhibition of oxidative stress.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aspartato Aminotransferases / Superóxido Dismutase / Carbono / Tetracloreto de Carbono / Catalase / Ratos Sprague-Dawley / Estresse Oxidativo / Hepatócitos / Alanina Transaminase / Éter Limite: Animais Idioma: Inglês Revista: Korean Journal of Veterinary Research Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aspartato Aminotransferases / Superóxido Dismutase / Carbono / Tetracloreto de Carbono / Catalase / Ratos Sprague-Dawley / Estresse Oxidativo / Hepatócitos / Alanina Transaminase / Éter Limite: Animais Idioma: Inglês Revista: Korean Journal of Veterinary Research Ano de publicação: 2011 Tipo de documento: Artigo