Functional Polymorphism in the Promoter Region of Matrix Metalloproteinase-9 is Strongly Associated with Acute Myocardial Infarction
Korean Circulation Journal
;
: 192-196, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-18989
ABSTRACT
BACKGROUND AND OBJECTIVES:
Matrix metalloproteinase-9 (MMP-9) plays an important role in the genesis of atherosclerotic plaque rupture and acute coronary syndrome (ACS), including an acute myocardial infarction (AMI). A single nucleotide polymorphism (SNP) in the MMP-9 promoter (-1562C>T) has recently been identified. This study investigated whether the SNP of the MMP-9 promoter is a significant risk factor for an AMI due to plaque rupture and if SNPs affect the transcription of the gene that elevates the MMP-9 expression level. SUBJECTS ANDMETHODS:
A polymerase chain reaction, followed by a restriction fragment length polymorphism analysis, was performed in 173 control participants and 206 AMI patients. The serum levels of MMP-9 in the groups with or without the SNP were measured, using ELISA, and compared.RESULTS:
There was a significantly higher incidence of the -1562C>T MMP-9 polymorphism in the AMI compared to the control group (27.6% vs. 17.9%, p=0.04). A multiple logistic regression analysis of the risk factors for coronary artery disease and the MMP-9 polymorphism showed the MMP-9 polymorphism to be an important factor in the prediction of an AMI (odds ratio 1.67, 95% confidence interval 1.02-2.67, p=0.04).CONCLUSION:
The -1562C>T polymorphism in the MMP-9 promoter is a definite risk factor for an AMI, and is associated with elevated MMP-9 expression. These results suggest that a SNP in the MMP-9 promoter is strongly associated with an Acute Myocardial Infarction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ruptura
/
Doença da Artéria Coronariana
/
Polimorfismo de Fragmento de Restrição
/
Ensaio de Imunoadsorção Enzimática
/
Modelos Logísticos
/
Reação em Cadeia da Polimerase
/
Incidência
/
Fatores de Risco
/
Regiões Promotoras Genéticas
/
Metaloproteinase 9 da Matriz
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2005
Tipo de documento:
Artigo
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