The causes of primary amenorrhea / 대한산부인과학회잡지

ABSTRACT

OBJECTIVE: To identify the causes of primary amenorrhea in the Korean population. METHODS: We reviewed the available medical records of the 100 patients who had visited the Department of Obstetrics and Gynecology at Seoul National University Hospital with the complaint of primary amenorrhea and examined their karyotypes between January 1989 and December 2000. Review of history, physical examination, laboratory findings, imaging studies, and operative findings was done, when needed. RESULTS: The mean age at diagnosis was 25.1+/-6.1 (mean+/-S.D.) years of age, ranged 14 to 40. Mllerian agenesis was the most common cause (40.0%), followed by primary ovarian failure (33.0%), and then followed by hypothalamic-pituitary failure (12.0%). Androgen insensitivity syndrome and Swyer syndrome were found in four patients (4.0%), respectively. CONCLUSION: This study shows that the common cases of primary amenorrhea in Korean women are Mllerian agenesis, primary ovarian failure and hypothalamic-pituitary failure.