Tumor Angiogenesis as a Predictor of Malignancy Potential and Prognosis in Gastric Carcinoma / 대한암학회지
Journal of the Korean Cancer Association
;
: 19-25, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-189985
ABSTRACT
PURPOSE:
In order to evaluate the clinical relevance of angiogenesis in patients with gastric cancer, we investigated the microvessel count in gastric cancer tissues and compared the results with several clinicopathologic factors and prognosis. MATERIALS ANDMETHODS:
A total of 256 patients with gastric cancer who underwent curative surgery were included in this study. Microvessel count was determined by im-munohistochemical staining using monoclonal antibody against factor VIII-related antigen.RESULTS:
The statistical significance between the microvessel count and clinicopathologic factors (age, sex, tumor invasion, lymph node involvement, histologic type) was analized. The tumor stage and histologic type were correlated with microvessel count. And also there was statistical significance with survival rate and recurrence-free survival rate between high (microvessel count> or =42) and low angiogeneic group (microvessel count< 42). The Cox's proportional hazard model showed that stage, histologic type, angiogeneic score were one of the significant and independent prognostic variables.CONCLUSION:
The tumor angiogenesis of gastric carcinoma may be independent prognostic factor for predicting recurrence and survival.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Recidiva
/
Neoplasias Gástricas
/
Fator de von Willebrand
/
Modelos de Riscos Proporcionais
/
Taxa de Sobrevida
/
Microvasos
/
Linfonodos
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Cancer Association
Ano de publicação:
2000
Tipo de documento:
Artigo
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