Comparison of etomidate and propofol on intubating conditions and the onset time associated with cisatracurium administration / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 136-140, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-190110
ABSTRACT
BACKGROUND:
This study compared intubating conditions and the onset time associated with administration of cisatracurium, a nondepolarizing neuromuscular blocker with a relatively slow onset, according to prior injection of one of two intravenous anesthetic agents propofol or etomidate.METHODS:
Forty-six female patients, undergoing general anesthesia and endotracheal intubation for elective surgery, were randomized to two groups; group P were administered propofol (2 mg/kg) prior to cisatracurium (0.2 mg/kg); group E were administered etomidate (0.3 mg/kg) prior to cisatracurium (0.2 mg/kg). We measured intubating conditions and the onset time according to the types of intravenous anesthetic administered. Measurements of heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were taken immediately prior to induction; immediately and 1 min after IV anesthetic administration; and immediately and 1, 2, 3, 4, 5, 7, and 15 min after endotracheal intubation.RESULTS:
Intubating conditions were superior in group E compared with group P (P = 0.009). The average onset time of cisatracurium was more rapid in group E (155.74 +/- 32.92 s vs. 185.26 +/- 38.57 s in group P; P = 0.008). There were no group differences in SBP, DBP, and HR following intravenous anesthetic drug injection and endotracheal intubation. However, SBP and DBP were substantially higher in group E after endotracheal intubation.CONCLUSIONS:
Etomidate improves intubating conditions and provide a more rapid onset time of cisatracurium during anesthetic induction compared to propofol.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pressão Sanguínea
/
Propofol
/
Bloqueio Neuromuscular
/
Etomidato
/
Frequência Cardíaca
/
Intubação Intratraqueal
/
Anestesia Geral
/
Anestésicos
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2015
Tipo de documento:
Artigo
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