Responses and adverse effects of carboplatin-based chemotherapy for pediatric intracranial germ cell tumors / 소아과
Korean Journal of Pediatrics
; : 128-132, 2011.
Article
em En
| WPRIM
| ID: wpr-190235
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Cisplatin-based chemotherapy has been commonly used for the treatment of intracranial germ cell tumors (IC-GCTs). However, this treatment exhibits some adverse effects such as renal problems and hearing difficulty. Carboplatin-based chemotherapy was administered to pediatric patients with IC-GCTs from August 2004 at the Samsung Medical Center. In this study, we assessed the responses and adverse effects of carboplatin-based chemotherapy in pediatric IC-GCTs patients according to the risk group, and compared the results with those of the previous cisplatin-based chemotherapy. METHODS: We examined 35 patients (27 men and 8 women) diagnosed with IC-GCTs between August 2004 and April 2008 and received risk-adapted carboplatin-based chemotherapy at the Samsung Medical Center. Patients were divided into either low-risk (LR) or high-risk (HR) groups and a retrospective analysis was performed using information from the medical records. RESULTS: Although hematological complications were common, hearing difficulties or grade 3 or 4 creatinine level elevation were not observed in patients who underwent carboplatin-based chemotherapy. The frequency of febrile neutropenia did not differ between the risk groups. The overall survival was 100% and event-free survival (EFS) was 95.7%. The EFS rate was 100% in the LR group and 90% in the HR group, respectively. CONCLUSION: Despite their common occurrence in high-risk patients, no lethal hematological complications were associated with carboplatin-based treatment. The current carboplatin-based chemotherapy protocol is safe and effective for the treatment of pediatric patients with IC-GCTs.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Estudos Retrospectivos
/
Carboplatina
/
Neoplasias Embrionárias de Células Germinativas
/
Intervalo Livre de Doença
/
Creatinina
/
Células Germinativas
/
Audição
/
Neutropenia
Tipo de estudo:
Guideline
/
Observational_studies
Limite:
Humans
/
Male
Idioma:
En
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2011
Tipo de documento:
Article