The Effect of Mitomycin C on the Holmium Laser Sclerostomy in Rabbits

ABSTRACT

This experiment is to evaluate the effects of subconjunctival mitorrycin injection on the holmium laser sclerostomy in rabbits. Three hours before laser sclerostomy, subconjunctival injection of normal saline(in control group, n=10 yes) or 0.04% mitomycinGn experiment group, n=10 eyes) was performed. After laser sclerostomy, change of intraocular pressure and appearance of filtering bleb were observed in each group. The duration of success with low intraocular pressure and presence of filtering blebs were evaluated. The duration of success was 5.1 +/- 2.5 days in control group and 29.8 +/- 12.6 days in experiment group. In the former, mean intraocular pressure was not significantly low compared with preoperative one five days after sclerostomy, but latter showed significantly low intraocular pressure 35 days after operation. These results suggest that subconjunctival injection of 0.04% mitomycin C three hours before operation was effective to the success of holmium laser sclerostomy.