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Comparison of Optical Coherence Tomographic Assessment between First- and Second-Generation Drug-Eluting Stents
Yonsei Medical Journal ; : 524-529, 2012.
Artigo em Inglês | WPRIM | ID: wpr-190370
ABSTRACT

PURPOSE:

There is a lack of sufficient data in comparison of optical coherence tomographic (OCT) findings between first- and second-generation drug-eluting stents (DES). Compared to first-generation (i.e., sirolimus- or paclitaxel-eluting stents), second-generation DESs (i.e., everolimus- or biolinx-based zotarolimus-eluting stents) might have more favorable neointimal coverage. MATERIALS AND

METHODS:

Follow-up OCT findings of 103 patients (119 lesions) treated with second-generation DESs were compared with those of 139 patients (149 lesions) treated with first-generation DESs. The percentage of uncovered or malapposed struts, calculated as the ratio of uncovered or malapposed struts to total struts in all OCT cross-sections, respectively, was compared between the two groups.

RESULTS:

Both DES groups showed similar suppression of neointimal hyperplasia (NIH) on OCT (mean NIH cross-sectional area; second- vs. first-generation=1.1+/-0.5 versus 1.2+/-1.0 mm2, respectively, p=0.547). However, the percentage of uncovered struts of second-generation DESs was significantly smaller than that of first-generation DESs (3.8+/-4.8% vs.7.5+/-11.1%, respectively, p<0.001). The percentage of malapposed struts was also significantly smaller in second-generation DESs than in first-generation DESs (0.4+/-1.6% vs.1.4+/-3.7%, respectively, p=0.005). In addition, intra-stent thrombi were less frequently detected in second-generations DESs than in first-generation DESs (8% vs. 20%, respectively, p=0.004).

CONCLUSION:

This follow-up OCT study showed that second-generation DESs characteristically had greater neointimal coverage than first-generation DESs.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Angiografia Coronária / Tomografia de Coerência Óptica / Stents Farmacológicos / Neointima Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Angiografia Coronária / Tomografia de Coerência Óptica / Stents Farmacológicos / Neointima Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2012 Tipo de documento: Artigo