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A Case of Pulmonary Thromboembolism with JAK2 Mutation / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 351-355, 2009.
Artigo em Coreano | WPRIM | ID: wpr-190768
ABSTRACT
The incidence of pulmonary thromboembolism increases with age. The risk factors of pulmonary thromboembolism include surgery, malignancy, obesity, lupus anticoagulants, and vascular conditions such as deep vein thrombosis. Thromboembolism in younger patients or in unusual locations, the possibility of primary thrombophilic conditions should be considered. Primary thrombophilic states include myeloproliferative disorders (MPD). JAK2 V617F mutation is found commonly in patients diagnosed with MPD, in 90~95% of polycythemia vera (PV) and in 50~60% of essential thrombocytosis (ET) patients. Sometimes the JAK2 V617F mutation is found in cases without MPD. The relationship between JAK2 V617F mutation and thrombosis has not been defined. Recently, clinical evidence suggests that this mutation may be variably associated with thrombosis. We present one case of pulmonary thromboembolism in a young patient, who was positive for the JAK2 V617F mutation and did not have MPD.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Policitemia Vera / Embolia Pulmonar / Trombocitose / Tromboembolia / Trombose / Incidência / Fatores de Risco / Trombose Venosa / Anticoagulantes / Transtornos Mieloproliferativos Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Policitemia Vera / Embolia Pulmonar / Trombocitose / Tromboembolia / Trombose / Incidência / Fatores de Risco / Trombose Venosa / Anticoagulantes / Transtornos Mieloproliferativos Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2009 Tipo de documento: Artigo