Comparison of Methods for the Detection of Anti-HBs for Hepatitis B Vaccination Program in Korea / 예방의학회지
Korean Journal of Preventive Medicine
; : 226-230, 2000.
Article
em Ko
| WPRIM
| ID: wpr-191286
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: The purpose of this study was to suggest a proper method for the detection of heaptitis B surface antibody(anti-HBs) in a screening program for hepatitis B vaccination. METHODS: Sensivitity, specificity and predictive values were compared between Immunochromatographic assay (ICA) and passive hemagglutination(PHA) in 978 subjects(565 males, 413 females, 19-78 years ranging in age, mean 46.5 years old). EIA was used as a standard method for the detection of HBsAb. RESULTS: Sensitivity in the detection of anti-HBs of PHA and ICA was 88.7% and 94.9%, specificity was 94.3% and 96.6%, negative predictive value was 96.5% and 98.0%, and positive predictive value was 82.3% and 91.3%, respectively. False negative rate(11.3%) of PHA was higher than that(5.1%) of ICA. The higher the titer of anti-HBs in EIA was, the lower the false negative rate was. There was no false negative result in the cases with 101mIU/ml or more in EIA. CONCLUSION: We suggest that ICA should be the choice of screening method in the detection of anti-HBs in Hepatitis B vaccination program.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Programas de Rastreamento
/
Cromatografia de Afinidade
/
Sensibilidade e Especificidade
/
Vacinação
/
Hepatite
/
Hepatite B
/
Coreia (Geográfico)
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Korean Journal of Preventive Medicine
Ano de publicação:
2000
Tipo de documento:
Article