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Effect of Hypophysectomy, Adrenalectomy, and Thyroidectomy on the Beta-Cells of the Islets of Langerhans of the Pancreas
Yonsei Medical Journal ; : 1-9, 1969.
Artigo em Inglês | WPRIM | ID: wpr-191416
ABSTRACT
Prolonged administration of anterior hypophyseal, adrenocortical, or thyroid hormones is known to cause degeneration, degranulation and necrosis of the beta-cells in the Langerhans islets of the pancreas. However, the effects of extirpation of these endocrine glands upon the Langerhans islets has not been reported, a1though it is known that removal of any of these glands bring about hypoglycemia, decreased tissue uptake of glucose, and increased tissue sensitivity to insulin. The present investigation is studies of the morphologic alterations of the beta-cells in the Langerhans islets following hypophysectomy, adrenalectomy, or thyroidectomy in rats. Hypophysectomy, adrenalectomy, and thyroidectomy, all induce similar morphologic alterations in the beta-cells of the islets. These consist of increased beta-cell population, the accumlnation of beta-granules, and atrophy of the individual betacell. Therefore, these changes are considered to be not specific following the withdrawal of specific hormones but a common effect of the hypoglycemia due to removal of the hypophysis, adrenals, or thyroid glands. A similar common degeneration of the beta-cells due to hyperglycemia occurs when hormones of these endocrine glands are given excessively.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Atrofia / Coloração e Rotulagem / Tireoidectomia / Tiroxina / Glicemia / Ilhotas Pancreáticas / Corticosteroides / Adrenalectomia / Diabetes Mellitus / Glicogênio Limite: Animais Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 1969 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Atrofia / Coloração e Rotulagem / Tireoidectomia / Tiroxina / Glicemia / Ilhotas Pancreáticas / Corticosteroides / Adrenalectomia / Diabetes Mellitus / Glicogênio Limite: Animais Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 1969 Tipo de documento: Artigo