Effect of Transdermal Fentanyl Patches on the Motility of the Sphincter of Oddi
Gut and Liver
; : 368-372, 2010.
Article
em En
| WPRIM
| ID: wpr-191438
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: Pain is one of the most troublesome symptoms of pancreatitis. Transdermal fentanyl patches (TFPs) are long-acting analgesics with a reduced risk of dependency. This prospective study evaluated the effect of TFPs on sphincter of Oddi (SO) motility for the management of pain in pancreatitis. METHODS: SO manometry (SOM) was performed using triple-lumen catheters anterogradely inserted through the percutaneous transhepatic route during cholangioscopy in 16 patients. The basal pressure, amplitude, and frequency of the SO were assessed before and after applying a TFP at 24 hour at doses of 25 and 12.5microgram/hr, respectively. RESULTS: Two of 16 patients receiving a 25microgram/hr. TFP were excluded because of adverse side effects (headache and/or nausea). The mean basal pressure, amplitude, and frequency of SOM did not change significantly in the 25microgram/hr TFP group (n=4 patients). Parameters of SO function also did not significantly change in the 12.5microgram/hr TFP group (n=11 patients). CONCLUSIONS: TFPs below a dose of 25microgram/hr may not affect the motility of the SO. Administration of TFPs at lower dosages seems to be a safe analgesic treatment for the pain control of patients with pancreatitis without affecting the function of the SO.
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Índice:
WPRIM
Assunto principal:
Pancreatite
/
Fentanila
/
Estudos Prospectivos
/
Dependência Psicológica
/
Catéteres
/
Analgésicos
/
Manometria
/
Esfíncter da Ampola Hepatopancreática
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2010
Tipo de documento:
Article