Comparison of Serum Beta 2-Microglobulin and 24 hour Urinary Creatinine Clearance as a Prognostic Factor in Multiple Myeloma
Journal of Korean Medical Science
; : 639-644, 2006.
Article
em En
| WPRIM
| ID: wpr-191668
Biblioteca responsável:
WPRO
ABSTRACT
A new staging system for multiple myeloma (MM) has utilized serum concentrations of beta 2-microglobulin (S beta2 M) and albumin as important prognostic factors for survival. Since S beta2 M is an indicator of glomerular filtration rate, we compared the prognostic values of S beta2 M and 24-hr urinary creatinine clearance (Ccr) in patients with MM. We retrospectively reviewed the records of 170 MM patients from January 1996 to November 2003 whose 24-hr urinary Ccr was available at the time of diagnosis. We found that pretreatment S beta2 M was inversely related to Ccr (Spearman's correlation coefficient=-0.787). In univariate analysis, the hazard ratio (HR) of death was 1.043 (p<0.001) for S beta2 M and 0.985 (p<0.001) for Ccr. Multivariate analysis showed that S beta2 M (HR 1.030, p=0.010) and Ccr (HR 0.993, p=0.059) were significant prognostic factors in patients' survival. In conclusion, 24-hr urinary Ccr may be utilized for staging of patients with MM.
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WPRIM
Assunto principal:
Prognóstico
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Análise de Sobrevida
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Análise Multivariada
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Estudos Retrospectivos
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Microglobulina beta-2
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Creatinina
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Mieloma Múltiplo
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Estadiamento de Neoplasias
Tipo de estudo:
Observational_studies
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Prognostic_studies
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2006
Tipo de documento:
Article