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Primary Systemic Anaplastic Large Cell Lymphoma in a Single Korean Institution: Clinical Characteristics and Treatment Outcome
Journal of Korean Medical Science ; : 633-638, 2006.
Artigo em Inglês | WPRIM | ID: wpr-191669
ABSTRACT
Despite advances in the characterization of anaplastic large cell lymphoma (ALCL), little data is available on Asian patients. We report here upon single Korean institution's experience regarding the clinical characteristics and outcomes of ALCL. We performed a retrospective study of 32 adults with ALCL. Most of the patients received anthracycline-based chemotherapy. Ann Arbor stage III-IV, B symptoms, high-intermediate/ high International Prognostic Index (IPI), and extranodal disease at diagnosis were present in 56%, 44%, 41%, and 63%, respectively. Compared with Western studies, the male/female ratio (4.3) was markedly higher and skin (9%) and bone involvement (9%) were less frequent. The staining results for anaplastic lymphoma kinase were positive in 6 (33%) of 18 cases available. The complete response (CR) rate was 62% (95% CI, 44-80%). With a median follow-up of 51.0 months, 5 yr overall survival was 40+/-11%. The 3 yr relapse-free survival for the 18 patients who achieved CR was 74+/-12%. Age, performance status, lactate dehydrogenase, extranodal disease sites number, and IPI were correlated with treatment response and survival. Our data suggest that Korean ALCL patients appear to have a higher male/female ratio, less frequent skin/bone involvement, and lower CR rate compared with those of Western studies.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Análise de Sobrevida / Estudos Retrospectivos / Resultado do Tratamento / Linfoma Anaplásico de Células Grandes / Antígeno Ki-1 / Coreia (Geográfico) / Recidiva Local de Neoplasia / Estadiamento de Neoplasias Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Análise de Sobrevida / Estudos Retrospectivos / Resultado do Tratamento / Linfoma Anaplásico de Células Grandes / Antígeno Ki-1 / Coreia (Geográfico) / Recidiva Local de Neoplasia / Estadiamento de Neoplasias Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2006 Tipo de documento: Artigo