Fecal microbiota transplantation for refractory Crohn's disease
Intestinal Research
;
: 244-248, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-191814
ABSTRACT
Approximately one-third of patients with Crohn's disease do not respond to conventional treatments, and some experience significant adverse effects, such as serious infections and lymphoma, and many patients require surgery due to complications. Increasing evidence suggests that specific changes in the composition of gut microbiota, termed as dysbiosis, are a common feature in patients with inflammatory bowel disease (IBD). Dysbiosis can lead to activation of the mucosal immune system, resulting in chronic inflammation and the development of mucosal lesions. Recently, fecal microbiota transplantation, aimed at modifying the composition of gut microbiota to overcome dysbiosis, has become a potential alternative therapeutic option for IBD. Herein, we present a patient with Crohn's colitis in whom biologic therapy failed previously, but clinical remission and endoscopic improvement was achieved after a single fecal microbiota transplantation infusion.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapia Biológica
/
Doenças Inflamatórias Intestinais
/
Doença de Crohn
/
Colite
/
Disbiose
/
Transplante de Microbiota Fecal
/
Microbioma Gastrointestinal
/
Sistema Imunitário
/
Inflamação
/
Linfoma
Limite:
Humanos
Idioma:
Inglês
Revista:
Intestinal Research
Ano de publicação:
2017
Tipo de documento:
Artigo
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