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Effects of the Single Administration of the Anticholonergics, Trospium Chloride, on the Patients with Nocturia
Journal of the Korean Continence Society ; : 75-81, 2005.
Artigo em Coreano | WPRIM | ID: wpr-192232
ABSTRACT

PURPOSE:

The aim of this study was to evaluate the effects of the single administration of the anticholonergics, trospium chloride, in the nocturic patients without bladder outlet obstruction for mid-term. MATERIALS AND

METHODS:

We included the 22 male and 102 female patients with nocturia over 3 times and without bladder outlet obstruction. Exclusion criteria was under 15 ml/sec in maximal flow rate, over 30 ml in post-void residual urine, nocturnal polyuria and medication affecting lower urinary tract symptoms including alpha-blockers, sedatives, muscle relaxants. Based on voiding diary for 3 days, frequency of the nocturia, daytime frequency and frequency of the urgency and urge incontinence were measured at pretreatment, post-treatment 1st month, 3rd month and 6th month. Additionally maximal flow rate and post-void residual urine were also recorded at the same periods. Anticholinergics was administered in flexible dose.

RESULTS:

In frequency of nocturia, single administration of the anticholonergics improved significantly at post-treatment 1st, 3rd and 6th month compared to pre-treatment level. The more severe the frequency of the nocturia was, the more it was improved by medication but there is no significant difference. Daytime frequency is significantly improved 3 month and 6 month after medication. In urgency and urge incontinence, the significant improvement was also observed at post-treatment 3rd month and 6th month. The significant differences between pre-treatment and post-treatment were not demonstrated in maximal flow rate and post-void residual urine. Dry mouth was the most common side effect but mild and tolerable.

CONCLUSION:

The single administration of the trospium chloride demonstrated a clinically significant improvement in nocturia as well as symptoms of the overactive bladder and did not affect negatively on bladder contractility.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Poliúria / Bexiga Urinária / Obstrução do Colo da Bexiga Urinária / Antagonistas Colinérgicos / Bexiga Urinária Hiperativa / Incontinência Urinária de Urgência / Noctúria / Sintomas do Trato Urinário Inferior / Hipnóticos e Sedativos / Boca Limite: Feminino / Humanos / Masculino Idioma: Coreano Revista: Journal of the Korean Continence Society Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Poliúria / Bexiga Urinária / Obstrução do Colo da Bexiga Urinária / Antagonistas Colinérgicos / Bexiga Urinária Hiperativa / Incontinência Urinária de Urgência / Noctúria / Sintomas do Trato Urinário Inferior / Hipnóticos e Sedativos / Boca Limite: Feminino / Humanos / Masculino Idioma: Coreano Revista: Journal of the Korean Continence Society Ano de publicação: 2005 Tipo de documento: Artigo