Modulation of Melanin Synthesis by Amaranthus spp. L Seed Extract in Melan-a Cells
Natural Product Sciences
;
: 168-174, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-192322
ABSTRACT
Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components, was measured in the crude extract of AT.AT reduced the melanin content in melan-a melanocytes and down-regulated melanogenic enzyme activity such as tyrosinase, TRP-1 and TRP-2. By regulating melanogenic enzyme activity, AT may be a potential natural source for whitening agent. Myo-inositol was detected in AT by HPLC and may be one of the active compounds from AT involved in the regulation of anti-melanogenesis. In this study, we demonstrated that AT has anti-melanogenesis properties. This new function of amaranth may be useful in the development of new skin-whitening products and its value as food.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esqualeno
/
Água
/
Cromatografia Líquida de Alta Pressão
/
Monofenol Mono-Oxigenase
/
Amaranthus
/
Antígeno MART-1
/
Melaninas
/
Melanócitos
Idioma:
Inglês
Revista:
Natural Product Sciences
Ano de publicação:
2016
Tipo de documento:
Artigo
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