Anti-TNF-alpha Therapy for Ankylosing Spondylitis
Clinics in Orthopedic Surgery
;
: 28-33, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-192615
ABSTRACT
BACKGROUND:
This review evaluated the safety and efficacy of etanercept in patients with ankylosing spondylitis (AS).METHODS:
Of 59 patients with AS, this study reviewed 11 patients who were refractory to conventional therapy and treated with etanercept from September 2005 to January 2008. The mean follow-up duration was 13.6 months. The general improvement was evaluated by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and adverse effects, complications and inflammatory markers were also assessed.RESULTS:
The mean BASDAI decreased from 7.1 +/- 1.6 before treatment to 4.2 +/- 1.8 at 3 months after the etanercept treatment (p = 0.001). The mean erythrocyte sedimentation rate and C-reactive protein were decreased significantly by the etanercept treatment. The greatest improvement in symptoms was enthesitis, followed by skin involvement and morning stiffness. There was a significant difference in the improvement in BASDAI along with the follow up duration (p = 0.04). A serious infection was observed as a complication in 1 case.CONCLUSIONS:
These results suggest that etanercept can induce significant improvement in most patients with less damage. A trial of tumor necrosis factor inhibition is indicated in all AS patients who do not achieve adequate disease control with disease-modifying antirheumatic drugs, such as methotrexate, leflunomide etc. The patients treated with etanercept should be educated about the possibility of infection and monitored closely.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espondilite Anquilosante
/
Sedimentação Sanguínea
/
Proteína C-Reativa
/
Imunoglobulina G
/
Esquema de Medicação
/
Anti-Inflamatórios não Esteroides
/
Fator de Necrose Tumoral alfa
/
Receptores do Fator de Necrose Tumoral
/
Antirreumáticos
/
Injeções Subcutâneas
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics in Orthopedic Surgery
Ano de publicação:
2010
Tipo de documento:
Artigo
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