Normal Value of Fetal hemoglobin Concentration in Children

ABSTRACT

A study of normal value of fetal hemoglobin concentration at each age in 1213 cases (852 patients, 361 normal children) who visited Chonnam university hospital from June 1977 to November 1978 was performed by alkali denaturation method, and following results were obtained. 1) The mean value of Hgb F at each age in normal children group was 65.5+/-1.8% in newborn infants during 24 hours, 40.5+/-1.6% in 1 month, 24.3+/-1.2% in 2 months, 15.3+/-1.4% in 3 months, 4.5+/-1.2% in 1 year 1.3+/-0.5% in 5 years, 0.9+/-0.7% in 10 years, 0.5+/-0.3% in 15 years. 2) The mean value of Hgb F at each age in patients group was 68.6+/-2.5% in newborn infants during 24 hours, 42.5+/-1.7% in 1 month, 22.9+/-1.1% in 2 months, 15.2+/-0.9% in 3 months, 5.5+/-1.0% in 1 year, 1.4+/-0.4% in 5 years, 0.9+/-0.6% in 10 years, 0.6+/-0.2% in 15 years. 3) The mean value of Hgb F at each age in both group was 67.5+/-2.0% in newborn infants during 24 hours, 41.8+/-2.1% in 1 month, 23.4+/-1.9% in 2 months, 15.2+/-1.0% in 3 months, 5.1+/-1.1% in 1 year, 1.4+/-0.8% in 5 years, 0.9+/-0.2% in 10 years, 0.6+/-0.2% in 15 years. 4) No significant correlation was found in the concentration of Hgb F at each age between normal children group and patients group, and either in the concentration of Hgb F at each sex of two groups.