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Past, Present and Future of PDE5 Inhibitor / 대한남성과학회지
Korean Journal of Andrology ; : 49-60, 2008.
Artigo em Coreano | WPRIM | ID: wpr-192850
ABSTRACT
The phosphodiesterase type-5 inhibitors (PDE5-Is) sildenafil, vardenafil and tadalafil are widely used as first-line therapy for erectile dysfunction (ED). Since the approval of sildenafil in 1998, more than 40 million men worldwide have been successfully treated with PDE5-Is. Pharmacologically, the proven safety and high tolerance of PDE5-Is is an attractive tool to investigate further physiological functions of PDE5, for example the modulation of intracellular cyclic GMP (cGMP) pools. As cGMP is a key component of intracellular signaling this may provide novel therapeutic opportunities beyond ED even for indications in which chronic administration is necessary. The approval of sildenafil for the treatment of pulmonary hypertension in 2005 was a notable success in this area of research. A number of other potential new indications are currently in various phases of preclinical research and development. In recent years, extensive but very heterogeneous information has been published in this field. The aim of this review is to summarize existing preclinical and clinical knowledge and critically discuss the evidence to support potential future indications for PDE5 inhibitors.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Piperazinas / Purinas / Sulfonas / Triazinas / Carbolinas / GMP Cíclico / Nucleotídeo Cíclico Fosfodiesterase do Tipo 5 / Citrato de Sildenafila / Dicloridrato de Vardenafila / Tadalafila Limite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Andrology Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Piperazinas / Purinas / Sulfonas / Triazinas / Carbolinas / GMP Cíclico / Nucleotídeo Cíclico Fosfodiesterase do Tipo 5 / Citrato de Sildenafila / Dicloridrato de Vardenafila / Tadalafila Limite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Andrology Ano de publicação: 2008 Tipo de documento: Artigo