Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides
Genomics & Informatics
;
: 12-19, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-193409
ABSTRACT
Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms. Neuropeptides bind to post-synaptic receptors and elicit cellular effects like classical neurotransmitters. While each neuropeptide could have its own biological function, mass spectrometry (MS) allows for the identification of the precise molecular forms of each peptide without a priori knowledge of the peptide identity and for the quantitation of neuropeptides in different conditions of the samples. MS-based neuropeptidomics approaches have been applied to various animal models and conditions to characterize and quantify novel neuropeptides, as well as known neuropeptides, advancing our understanding of nervous system function over the past decade. Here, we will present an overview of neuropeptides and MS-based neuropeptidomic strategies for the identification and quantitation of neuropeptides.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Endopeptidases
/
Espectrometria de Massas
/
Neuropeptídeos
/
Ritmo Circadiano
/
Neurotransmissores
/
Modelos Animais
/
Depressão
/
Fenômenos Fisiológicos
/
Sinais Vitais
/
Sistema Nervoso
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2016
Tipo de documento:
Artigo
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