Role of 5-HT1A Receptors in Learning and Memory / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 271-279, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-193448
ABSTRACT
Growing evidence indicates that the serotonin system is important in learning and memory. In particular, several preclinical and clinical studies suggest that modulating the 5-HT1A receptor can influence learning and memory, and indeed, it has been observed that presynaptic 5-HT1A receptor agonists and postsynaptic 5-HT1A receptor antagonists tend to ameliorate the learning/memory impairment induced by various methods. In contrast, post-synaptic 5-HT1A receptor agonists tend to decrease the learning/memory function. These observations suggest the possibility that modulating neurotransmission mediated by the 5-HT1A receptor may be effective as a therapeutic strategy for enhancing learning and memory in various neuropsychiatric disorders. Unfortunately, there is no available discussion on the relationship between 5-HT1A receptor and learning/memory in Korea. This article reviews the clinical or preclinical literature on this issue.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Serotonina
/
Transmissão Sináptica
/
Receptor 5-HT1A de Serotonina
/
Coreia (Geográfico)
/
Aprendizagem
/
Memória
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2007
Tipo de documento:
Artigo
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