Curcumin attenuates the middle cerebral artery occlusion-induced reduction in gamma-enolase expression in an animal model / 한국실험동물학회지
Laboratory Animal Research
;
: 198-203, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-193812
ABSTRACT
Curcumin exerts a protective effect in cerebral ischemia through its anti-oxidant and anti-inflammatory activities. gamma-enolase is a glycolytic enzyme expressed in neurons that is known to exerts a neuroprotective effect. We investigated whether curcumin regulates gamma-enolase expression in focal cerebral ischemic injury in rats. Middle cerebral artery occlusion (MCAO) was performed to induce focal cerebral ischemia. Adult male rats were injected intraperitoneally with either vehicle or curcumin (50 mg/kg) 1 h after MCAO and cerebral cortex tissues were isolated 24 h after MCAO. We found that MCAO-induced injury resulted in a reduction in gamma-enolase expression in vehicle-treated animals using a proteomics approach. However, this reduction was attenuated in animals with MCAO treated with curcumin. Reverse-transcription PCR and Western blot analyses also showed that curcumin treatment prevented the MCAO injury-induced reduction in gamma-enolase expression. The results of this study suggest that curcumin exerts its neuroprotective function in focal cerebral ischemia by regulating the expression of gamma-enolase.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfopiruvato Hidratase
/
Córtex Cerebral
/
Isquemia Encefálica
/
Western Blotting
/
Reação em Cadeia da Polimerase
/
Fármacos Neuroprotetores
/
Artéria Cerebral Média
/
Infarto da Artéria Cerebral Média
/
Curcumina
/
Modelos Animais
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Laboratory Animal Research
Ano de publicação:
2015
Tipo de documento:
Artigo
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