Risk Factors of Failure of Ibuprofen Treatment in Preterm Infants with Hemodynamically Significant Patent Ductus Arteriosus / 대한주산의학회잡지
Korean Journal of Perinatology
;
: 257-265, 2014.
Artigo
em Coreano
| WPRIM
| ID: wpr-194011
ABSTRACT
PURPOSE:
In this study, the risk factors of failure of ibuprofen treatment in preterm infants with hemodynamically significant patent ductus arteriosus (hsPDA) were investigated.METHODS:
Among 403 preterm infants (<32 weeks gestation) born between January 2010 and December 2012, 125 infants treated with ibuprofen for hsPDA were retrospectively reviewed. The preterm infants were divided into the following groups according to their response to the 1st and 2nd cycles of ibuprofen treatment responder groups I and II, closure of the ductus arteriosus after the 1st and 2nd cycles of ibuprofen treatment; and non-responder groups I and II, persistency of hsPDA after the 1st and 2nd cycles of ibuprofen treatment.RESULTS:
One hundred twenty five infants were enrolled in the study 74 in responder group I, 51 in non-responder group I, 14 in responder group II, and 22 in non-responder group II. In non-responder group I, the gestational age and birth weight were smaller, the postnatal steroid treatment was more frequent, and the duration of mechanical ventilation and the days spent in the hospital were prolonged.I n non-responder group II, the gestational age and birth weight were smaller, the diameters of the ductus arteriosus were larger, and the inotropics use was more frequent.CONCLUSION:
Failure of ibuprofen treatment of hsPDA is associated with the diameter of the ductus arteriosus and with inotropics use. Obtaining data regarding these is expected to help in determining if early direct surgical ligation is needed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Respiração Artificial
/
Peso ao Nascer
/
Recém-Nascido Prematuro
/
Ibuprofeno
/
Estudos Retrospectivos
/
Fatores de Risco
/
Idade Gestacional
/
Canal Arterial
/
Permeabilidade do Canal Arterial
/
Ligadura
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Limite:
Humanos
/
Lactente
/
Recém-Nascido
Idioma:
Coreano
Revista:
Korean Journal of Perinatology
Ano de publicação:
2014
Tipo de documento:
Artigo
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