Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation
Endocrinology and Metabolism
;
: 11-17, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-194437
ABSTRACT
Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Transcrição
/
Disponibilidade Biológica
/
Expressão Gênica
/
Regiões Promotoras Genéticas
/
Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina
/
Proteína 2 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Isoformas de Proteínas
/
Fígado
/
Doenças Metabólicas
/
Obesidade
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Endocrinology and Metabolism
Ano de publicação:
2017
Tipo de documento:
Artigo
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