Gastroesophageal Reflux in Neurologically Impaired Children: What Are the Risk Factors?
Gut and Liver
;
: 232-236, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-194965
ABSTRACT
BACKGROUND/AIMS:
Neurologically impaired patients frequently suffer from gastrointestinal tract problems, such as gastroesophageal reflux disease (GERD). In this study, we aimed to define the risk factors for GERD in neurologically impaired children.METHODS:
From May 2006 to March 2014, 101 neurologically impaired children who received 24-hour esophageal pH monitoring at Severance Children’s Hospital were enrolled in the study. The esophageal pH finding and the clinical characteristics of the patients were analyzed.RESULTS:
The reflux index was higher in patients with abnormal electroencephalography (EEG) results than in those with normal EEG results (p=0.027). Mitochondrial disease was associated with a higher reflux index than were epileptic disorders or cerebral palsy (p=0.009). Patient gender, feeding method, scoliosis, tracheostomy, and baclofen use did not lead to statistical differences in reflux index. Age of onset of neurological impairment was inversely correlated with DeMeester score and reflux index. Age at the time of examination, the duration of the disease, and the number of antiepileptic drugs were not correlated with GER severity.CONCLUSIONS:
Early-onset neurological impairment, abnormal EEG results, and mitochondrial disease are risk factors for severe GERD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Escoliose
/
Baclofeno
/
Traqueostomia
/
Refluxo Gastroesofágico
/
Paralisia Cerebral
/
Fatores de Risco
/
Idade de Início
/
Doenças Mitocondriais
/
Trato Gastrointestinal
/
Eletroencefalografia
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Gut and Liver
Ano de publicação:
2017
Tipo de documento:
Artigo
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