ider (9) (q10)t (9;22) (q34;q11.2) as Secondary Karyotypic Aberration of Chronic Myelogeous Leukemia / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 266-270, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-195435
ABSTRACT
Although occasional patients with chronic myeloid leukemia (CML) have chromosomal changes other than Philadelphia chromosome early in the disease, in typical cases the 9;22 translocation remains the sole abnormality throughout the disease course in chronic phase. When disease progression occurs, however, 75-80% develop additional chromosome aberrations. These secondary changes sometimes precede the more aggressive manifestations hematologically and clinically and thus may serve as valuable prognostic indicators. ider (9) (q10)t (9;22) (q34;q11.2) is very rare and a recurrent chromosomal abnormality associated with acute lymphoblastic leukemias (ALL) and lymphoblastic crisis of CML. And ider (9) (q10)t (9;22) (q34;q11.2) is a lymphoid-specific rearrangement and the patients with this abnormality are of older age on average. They commonly show pre-B cell lineage immunophenotype and L2 morphology. We report a case of ider (9) (q10)t (9;22) (q34;q11.2) as secondary aberration in a patient with lymphoblastic crisis of CML.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cromossomo Filadélfia
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Leucemia
/
Crise Blástica
/
Aberrações Cromossômicas
/
Progressão da Doença
/
Células Precursoras de Linfócitos B
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Clinical Pathology
Ano de publicação:
1999
Tipo de documento:
Artigo
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