Apoptotic Effect of Macrophages against Mycobacterium tuberculosis
Journal of Bacteriology and Virology
;
: 312-318, 2016.
Artigo
em Coreano
| WPRIM
| ID: wpr-195567
ABSTRACT
Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tuberculose
/
Inalação
/
Macrófagos Alveolares
/
Morte Celular
/
Apoptose
/
Proteínas Reguladoras de Apoptose
/
Macrófagos
/
Mycobacterium
/
Mycobacterium tuberculosis
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Bacteriology and Virology
Ano de publicação:
2016
Tipo de documento:
Artigo
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