Advantages of the single nucleotide polymorphism-based noninvasive prenatal test
Journal of Genetic Medicine
;
: 66-71, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-195769
ABSTRACT
Down syndrome screening with cell-free DNA (cfDNA) in the maternal plasma has recently received much attention in the prenatal diagnostic field. Indeed, a large amount of evidence has already accumulated to show that screening tests with cfDNA are more sensitive and specific than conventional maternal serum and/or ultrasound screening. Globally, more than 1,000,000 of these noninvasive prenatal tests (NIPTs) have been performed to date. There are several different methods for NIPTs that are currently commercially available, including shotgun massively parallel sequencing, targeted massively parallel sequencing, and single nucleotide polymorphism (SNP)-based methods. All of these methods have their own advantages and disadvantages. In this review, I will focus specifically on the SNP-based NIPT.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Diagnóstico Pré-Natal
/
DNA
/
Programas de Rastreamento
/
Ultrassonografia
/
Síndrome de Down
/
Polimorfismo de Nucleotídeo Único
/
Sequenciamento de Nucleotídeos em Larga Escala
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Journal of Genetic Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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