Paracentric Inversions Found in Prenatal Diagnosis
Journal of Genetic Medicine
;
: 104-108, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-196055
ABSTRACT
PURPOSE:
This study was designed to confirm whether the paracentric inversions of fetuses and parents may be harmless. MATERIALS ANDMETHODS:
We report 10 cases (0.14%) with paracentric inversions among 7,181 prenatal cases observed during prenatal diagnosis performed at Cheil General Hospital between January 2009 and June 2013. We used cytogenetic GTL- and RBG-banding techniques.RESULTS:
Of the 10 cases, nine cases were transmitted from each of the parents, and one case was de novo. Nine cases were phenotypically normal up to one month of age after birth. One case was lost to follow-up. We present prenatal diagnosis and follow-up examination of the fetuses with paracentric inversion.CONCLUSION:
Based on our cases, most paracentric inversions are considered to be harmless. The precise identification of paracentric inversions might be clinically important and helpful for genetic counseling.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pais
/
Diagnóstico Pré-Natal
/
Amostra da Vilosidade Coriônica
/
Seguimentos
/
Citogenética
/
Parto
/
Perda de Seguimento
/
Feto
/
Aconselhamento Genético
/
Amniocentese
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Journal of Genetic Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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