Long-Term Tolerability of Escitalopram in Korean Adolescents
Journal of the Korean Academy of Child and Adolescent Psychiatry
;
: 207-212, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-196062
ABSTRACT
OBJECTIVES:
We investigated the long-term tolerability of escitalopram in Korean adolescents.METHODS:
The subjects were 37 adolescents, who had been diagnosed with depressive disorder in accordance to DSM-IV. Clinical effectiveness was assessed by Clinical Global Impression-Improvement (CGI-I) scale at the final follow-up visit. Tolerability was assessed through a medical record of the reason for discontinuation of escitalopram and documented adverse events.RESULTS:
The mean duration of treatment was 78.1+/-89.5 days, and the mean dosage was 10.0+/-4.4mg/day. Out of the total 37 patients, two (5%) patients sustained use of escitalopram. Twelve patients (32.4%) discontinued use of escitalopram due to target symptom remission, and 23 patients (61.9%) due to insufficient efficacy. Six patients (16.2%) had at least one documented adverse event. However, no suicidal ideation or self-injurious behavior was reported. Significant differences in clinical symptom improvement efficacy were seen between the patients who were receiving escitalopram for less than 8 weeks (4.3%, 1/13) and those for more than 8 weeks (92.9%, 13/14). There was no significant difference between the tolerability of monotherapy compared to the concomitant use group.CONCLUSION:
The results of this study suggest that long-term use of escitalopram may result in superior efficacy than short-term use, and is tolerable in Korean adolescents with depression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Citalopram
/
Prontuários Médicos
/
Seguimentos
/
Comportamento Autodestrutivo
/
Manual Diagnóstico e Estatístico de Transtornos Mentais
/
Depressão
/
Transtorno Depressivo
/
Ideação Suicida
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Humanos
Idioma:
Inglês
Revista:
Journal of the Korean Academy of Child and Adolescent Psychiatry
Ano de publicação:
2013
Tipo de documento:
Artigo
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